R.J. Anderson at FanGraphs has a fantastic breakdown of the Adrian Gonzalez trade market, showing an easy-to-read table outlining who needs a first baseman and then going through each team's prospect/competitive/cash situation to find five potential suitors. The Orioles basically come out in the top 3.
I think Gonzalez would be an excellent fit for the Orioles; it all comes down to cost. If the O's could snag the star first baseman without surrendering Matusz or Tillman, that seems like a pretty good deal. I don't know if that is realistic, however. My proposal: Felix Pie, Jake Arrieta, Brandon Erbe or Zach Britton and Caleb Joseph. This would give the Padres a center fielder immediately capable of playing at Petco Park, a pair of top pitching prospects that are close to Major League ready and a catching prospect that Baseball Prospectus calls "an excellent hitter with good barrel manipulation and some of the best plate coverage in the system." Note that this means the Orioles would surrender their #3, #4/#6 and #9 prospects, according to BP.
Is that enough? I don't know. It depends on San Diego's opinion of Pie and Joseph (who has yet to play above Frederick) and whether or not Arrieta and Erbe/Britton are viewed as having high enough ceilings. I doubt this would get the deal done, but it seems like a reasonable place to begin discussions.